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It gives hope to parents Gerry and Kate McCann that Maddie may yet be traceable, three-and-a-half years after she first went missing in Portugal.
A spokesman for the McCanns said an investigator had done 'absolutely the right thing' by going to police with his suspicions.
According to Marcelino Italiano the paedophile ring has taken a dozen other children, believing they can get away with anything.
He was quoted in The Sun newspaper as saying: 'I know these people were involved and I have been told that Madeleine may now be in America.'
The Angolan, who also works as a nightclub bouncer, has given in a dossier - including the names of two prominent Portuguese businessmen - to police in Huelva, south-west Spain, according to the newspaper.
The McCann's spokesman said: 'It is entirely appropriate that the police and any other law enforcement body now investigates these claims along with the private investigators currently searching for Madeleine.
'These investigations are now under way.'
Maddie was nearing her fourth birthday when she disappeared from the family's holiday apartment in Praia da Luz, Algarve on May 3, 2007. Her parents were dining with friends at the time.
She has still not been found, despite a massive police investigation and huge publicity worldwide.
The formal inquiry in Portugal over Maddie's disappearance was officially shelved in July 2008, but private detectives paid by the McCanns have continued the hunt.
There have been reports of sightings from around the world, but she has still not been found.
