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leukemia:
Rather than cancer "of the blood," as is commonly thought, leukemia is a cancer of the organs that make the blood: the BONE MARROW and LYMPH SYSTEM. Red and white blood cells, platelets, and lymph cells originate in the bone marrow and lymph system, where they "mature" before entering the bloodstream. While the same process takes place in a person with leukemia, the number of cells produced, the rate at which they are produced, and their ability to function are altered.

The term "leukemia" comes from the Greek and means "white blood." Although there are some exceptions, such as ERYTHROLEUKEMIA, most leukemias cause white blood cells to reproduce abnormally, which is harmful in several ways. An overabundance of abnormal white blood cells in the bloodstream can infiltrate vital organs and glands, causing them to enlarge and/or malfunction; or they can crowd out healthy cells and prevent the bone marrow from producing sufficient levels of normally functioning red, white, and clotting cells platelets.

Leukemia accounts for about 5% of all cancer cases in the United States. In 1999 there were about 30,200 cases diagnosed in the United States and about 22,100 deaths. Leukemia is the most common childhood cancer in the United States. The most common type of leukemia occurring in children is acute lymphocytic leukemia (ALL), accounting for 45%; it is most likely to occur in children aged 6 and younger. The second most common leukemia in children is acute nonlymphocytic leukemia (ANLL). However, leukemia is far more common in older adults. More than half of all leukemias occur in people over 60 years of age. Men are affected by leukemia about 30% more often than women. It occurs slightly more often in whites than blacks, and Jewish people have a slightly higher incidence than other whites.

About half the newly diagnosed leukemias are acute (immature cells still involved in the growth process are affected and the disease progresses rapidly), and half are chronic (cells in a more advanced stage of development are affected and the disease progresses slowly). Chronic leukemia can become acute in some circumstances.

The causes of leukemia are not fully understood, but there are factors that are known to increase the risk of developing leukemia. There is evidence that radiation can induce leukemia; the greater the exposure, the higher the risk. There can be a delay of up to 20 years before leukemia develops in a person who has been exposed to excessive radiation. In Japan, among the people who survived the largest radiation doses from the atomic bombs, only 1 in 40 developed leukemia, which illustrates that susceptibility to radiation-induced leukemia varies from person to person. Since the potential hazard of excess exposure to X RAYS has become widely known, exposure to it has declined.

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